منابع مشابه
Dermal-epidermal Junction under Electron Microscopy
Over the past decade, protein and genetic abnormalities have gradually been unveiled for most types of hereditary epidermolysis bullosa (EB). Much understanding has been gained regarding the underlying pathogenic mechanisms of this group of diseases. To appreciate these new advances and their clinical applications, it is important to understand the basic molecular organisation of the normal der...
متن کاملThe impact of intrinsic ageing on the protein composition of the dermal-epidermal junction
The dermal-epidermal junction of human skin exhibits age-related remodelling, resulting in a flattened appearance and reduced surface area. Despite this, a paucity of information is available regarding which protein components change with advancing age. Here we report a significant reduction in the protein distribution of collagen IV (P<0.0001), collagen VII (P<0.001), collagen XVII (P<0.01), i...
متن کاملDegradation of the epidermal-dermal junction by proteolytic enzymes from human skin and human polymorphonuclear leukocytes
The degradation of normal human skin by the human polymorphonuclear leukocyte proteinases cathepsin G and elastase, and by a human skin chymotrypsin-like proteinase that appears to be a mast cell constituent, was examined. Enzymes were incubated with fresh, split-thickness skin for up to 8 h; the tissue was examined ultrastructurally and immunohistochemically using antibodies to known basement ...
متن کاملThe dermal-epidermal junction of human skin contains a novel laminin variant
We report the identification of a novel laminin variant that appears to be unique to a subset of epithelial basement membranes. The variant contains two chains electrophoretically and immunologically identical to the B1 and B2 chains. Epitopes contained in the laminin A chain are absent from the molecule, and a 190-kD chain substitutes for the A chain. V8 protease analysis and Western blotting ...
متن کاملAutomated delineation of dermal-epidermal junction in reflectance confocal microscopy image stacks of human skin.
Reflectance confocal microscopy (RCM) images skin noninvasively, with optical sectioning and nuclear-level resolution comparable with that of pathology. On the basis of the assessment of the dermal-epidermal junction (DEJ) and morphologic features in its vicinity, skin cancer can be diagnosed in vivo with high sensitivity and specificity. However, the current visual, qualitative approach for re...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1975
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12598050